Year: 2013
Type: editorial
Abstract: Necdin, a member of the melanoma antigen gene (MAGE) family, originally identified to suppress cell proliferation in post-mitotic neurons, facilitates the entry of the cell into cell cycle, functions like retinoblastoma (Rb) protein, and acts as a transcriptional repressor that recognizes guanosine (G)-rich DNA sequences. Necdin also binds to p53 and inhibits p53-dependent apoptosis in these cells, demonstrating its function as an endogenous anti-mitotic and anti-apoptotic protein in post-mitotic neurons [1]. The necdin gene is located on chromosome 15 in human and its expression is controlled through genomic imprinting; it is one of the genes that have been associated with the human Prader-Willi syndrome, a genetic neuro-behavioral disorder [2]. Necdin is expressed in some stem or undifferentiated progenitor cells such as mesoangioblast
Source: Oncotarget
Authors: Takashi Asai, Yan Liu, Stephen D Nimer
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W2156418846