Work

Tumor-expressed IL-17D recruits NK cells to reject tumors

Year: 2014

Type: article

Abstract: Antitumor immunity suppresses tumorigenesis, but we do not understand how transformed cells initiate those immune responses that are essential for effective tumor immunosurveillance. Using the 3-MCA fibrosarcoma model, we identified IL-17D as a tumor-expressed cytokine that recruits natural killer cells, leading to the polarization of M1 macrophages and tumor rejection.

Source: OncoImmunology

DOI: 10.4161/21624011.2014.954853

Authors: Robert Saddawi-Konefka, Timothy O’Sullivan, Emilie T Gross, Allen Washington, Jack D Bui

Institutions: University of California System, University of California San Diego, Memorial Sloan Kettering Cancer Center

Language: English

Topic: Immune Cell Function and Interaction

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,913