Escherichia coli mazEF -Mediated Cell Death Is Triggered by Various Stressful Conditions
Year: 2004
Type: article
Abstract: mazEF is an Escherichia coli suicide module specific for a stable toxin and a labile antitoxin. Inhibiting mazEF expression appeared to activate the module to cause cell death. Here we show that several stressful conditions, including high temperatures, DNA damage, and oxidative stress, also induce mazEF-mediated cell death. We also show that this process takes place only during logarithmic growth and requires an intact relA gene.
Source: Journal of Bacteriology
Authors: Ronen Hazan, Boaz Sat, Hanna Engelberg-Kulka
Institutions: Hebrew University of Jerusalem, Hadassah Medical Center
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2156539285