Work

A comparative study of selenium concentration and glutathione peroxidase activity in normal and breast cancer patients

Year: 2008

Type: article

Abstract: OBJECTIVE: The present study was undertaken to compare plasma Se values and glutathione peroxidase (GPX) activity in normal and breast cancer patients. DESIGN: In a case-control study, forty-five breast cancer patients and the same number of healthy women were randomly selected from their population. Se was measured in plasma by atomic absorption spectrophotometry and GPX activity in erythrocytes was measured using a standard spectrophotometric method. RESULTS: Plasma Se concentration in healthy women and breast cancer patients was in the normal range, with no statistically significant difference observed between the two groups (138.40 (sd 40.36) microg/l v. 132.15 (sd 35.37) microg/l, respectively). Erythrocyte GPX activity was significantly (P<0.01) higher in breast cancer patients (24.81 (sd 11.66) U/g Hb) compared with healthy women (20.29 (sd 4.24) U/g Hb). CONCLUSION: The present study indicated that Se deficiency was not a problem in the participants, and sufficient quantity of this element could increase GPX activity to have a protective effect against oxidative damage.

Source: Public Health Nutrition

DOI: 10.1017/s1368980008001924

Authors: Masoumeh Moradi, Mohammad Hassan Eftekhari, Abdolrasoul Talei, Abdolreza Rajaei Fard

Institution: Shiraz University of Medical Sciences

Language: English

Topic: Selenium in Biological Systems

Subfield: Nutrition and Dietetics

Field: Nursing

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Shiraz University of Medical Sciences, Shiraz University