Work

Helical poly(arginine) mimics with superior cell-penetrating and molecular transporting properties

Year: 2013

Type: article

Abstract: Poly(arginine) mimics bearing long hydrophobic side chains adopt stable helical conformation and exhibit helix-related cell-penetrating properties. Elongating polypeptide backbone length and increasing side chain hydrophobicity further increase the helicities of poly(arginine) mimics. They show superior cell membrane permeability up to two orders of magnitude higher than that of HIV-TAT peptide and excellent DNA and siRNA delivery efficiencies in various mammalian cells.

Source: Chemical Science

DOI: 10.1039/c3sc51328a

Authors: Haoyu Tang, Lichen Yin, Kyung Hoon Kim, Jianjun Cheng

Institution: University of Illinois Urbana-Champaign

Language: English

Topic: RNA Interference and Gene Delivery

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Science Foundation, National Institutes of Health, National Institute of Biomedical Imaging and Bioengineering