Analysis of Bordetella pertussis Agglutinin Titers during an Outbreak of Pertussis at a University in Japan
Year: 2010
Type: article
Study design: Observational Study
Abstract: In 2007, a large outbreak of pertussis occurred at a university in Japan. Initially, a student, suffering from nocturnal cough and post-tussive vomiting for 3 weeks was diagnosed with pertussis. During the subsequent outbreak, 361 university students and staff members presented with a primary complaint of a cough. In the present study, we analyzed bacterial agglutinin titers against two Bordetella pertussis strains, Yamaguchi (epidemic strain) and Tohama (vaccine strain), in 310 patients with a cough and evaluated its diagnostic accuracy for adolescent and adult pertussis. These serological analyses showed a significant difference (P<0.001) in the levels of Yamaguchi agglutinin titer, but not in those of Tohama agglutinin titer, between patient and healthy adult groups. Therefore, the bacterial agglutination assay against strain Yamaguchi may be a useful tool for diagnosis of adolescent and adult pertussis, especially in young adults, when an agglutinin titer cutoff value of >or=160x is used in combination with clinical symptoms and other clinical laboratory tests.
DOI: 10.7883/yoken.63.108
Authors: Hiroshi Kamano, Tomomi Mori, Hajime Maeta, Tomohiko Taminato, Toshihiko Ishida, Nobuhito Kishimoto, Tomohiko Katami, Makoto Sato, Kazunari Kamachi, Yoshiyuki Mochida
Language: English
Subfield: Microbiology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W4293021244