Work

Analysis of Vaginal Cell Populations during Experimental Vaginal Candidiasis

Year: 1999

Type: article

Abstract: Studies with an estrogen-dependent murine model of vaginal candidiasis suggest that local cell-mediated immunity (CMI) is more important than systemic CMI for protection against vaginitis. The present study, however, showed that, compared to uninfected mice, little to no change in the percentage or types of vaginal T cells occurred during a primary vaginal infection or during a secondary vaginal infection where partial protection was observed. Furthermore, depletion of polymorphonuclear leukocytes (PMN) had no effect on infection in the presence or absence of pseudoestrus. These results indicate a lack of demonstrable effects by systemic CMI or PMN against vaginitis and suggest that if local T cells are important, they are functioning without showing significant increases in numbers within the vaginal mucosa during infection.

Source: Infection and Immunity

DOI: 10.1128/iai.67.6.3135-3140.1999

Authors: Paul L. Fidel, Wei Luo, Chad Steele, Joseph Chabain, Marc Baker, Floyd Wormley

Institutions: Louisiana State University, University Medical Center New Orleans, Louisiana State University Health Sciences Center New Orleans

Language: English

Topic: Reproductive tract infections research

Subfield: Microbiology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of Allergy and Infectious Diseases