Work

Rapid and Selective Crystallization of Acetaminophen Using Metal-Assisted and Microwave-Accelerated Evaporative Crystallization

Year: 2012

Type: article

Abstract: In this paper, we demonstrate the application of Metal-Assisted and Microwave-Accelerated Evaporative Crystallization (MA-MAEC) technique to rapid and selective crystallization of a small drug compound. i.e. acetaminophen. Subsequent characterization of the crystals by optical microscopy, powder X-ray diffraction (PXRD) and Raman spectroscopy showed quantitatively selective growth of different crystal forms at various experimental conditions. Acetaminophen crystals were grown predominantly as Form I (99%) on blank glass slides at room temperature. Form II crystals with 39% purity grown on SIFs using microwave energy.

Source: Nano Biomedicine and Engineering

DOI: 10.5101/nbe.v4i1.p35-40

Authors: Muzaffer Mohammed, Maleeha F Syed, Mona J Bhatt, Eugene J Hoffman, Kadir Aslan

Institution: Morgan State University

Language: English

Topic: Crystallization and Solubility Studies

Subfield: Materials Chemistry

Field: Materials Science

Domain: Physical Sciences

Open Access status: diamond

Funders: National Institutes of Health, National Institute of Biomedical Imaging and Bioengineering

Award: Ultra Fast and Sensitive Fluorescence-Based Clinical Assays