Work

Chronic Fatigue and Personality: A Twin Study of Causal Pathways and Shared Liabilities

Year: 2013

Type: article

Abstract: BACKGROUND: The etiology of chronic fatigue syndrome (CFS) remains unknown. Personality traits influence well-being and may play a role in CFS and unexplained chronic fatigue. PURPOSE: This study aimed to examine the association of emotional instability and extraversion with chronic fatigue and CFS in a genetically informative sample. METHODS: We evaluated 245 twin pairs for two definitions of chronic fatigue. They completed the Neuroticism and Extraversion subscales of the NEO Five Factor Inventory. Using a co-twin control design, we examined the association between personality and chronic fatigue. RESULTS: Higher emotional instability was associated with both definitions of chronic fatigue and was confounded by shared genetics. Lower extraversion was also associated with both definitions of fatigue, but was not confounded by familial factors. CONCLUSIONS: Both emotional instability and extraversion are related to chronic fatigue and CFS. Whereas emotional instability and chronic fatigue are linked by shared genetic mechanisms, the relationship with extraversion may be causal and bidirectional.

Source: Annals of Behavioral Medicine

DOI: 10.1007/s12160-012-9463-5

Authors: Brian Poeschla, Eric Strachan, Elizabeth Dansie, Dedra S. Buchwald, Niloofar Afari

Institutions: University of Washington, University of California San Diego, VA San Diego Healthcare System, Center of Excellence for Stress and Mental Health

Language: English

Topic: Fibromyalgia and Chronic Fatigue Syndrome Research

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Heart, Lung, and Blood Institute, National Institute of Allergy and Infectious Diseases, National Institute of Arthritis and Musculoskeletal and Skin Diseases