Work

A Potential Role of the Curry Spice Curcumin in Alzheimers Disease

Year: 2005

Type: article

Abstract: There is substantial in-vitro data indicating that curcumin has antioxidant, anti-inflammatory, and anti-amyloid activity. In addition, studies in animal models of Alzheimer's disease (AD) indicate a direct effect of curcumin in decreasing the amyloid pathology of AD. As the widespread use of curcumin as a food additive and relatively small short-term studies in humans suggest safety, curcumin is a promising agent in the treatment and/or prevention of AD. Nonetheless, important information regarding curcumin bioavailability, safety and tolerability, particularly in an elderly population is lacking. We are therefore performing a study of curcumin in patients with AD to gather this information in addition to data on the effect of curcumin on biomarkers of AD pathology.

Source: Current Alzheimer Research

DOI: 10.2174/1567205053585882

Authors: John Ringman, Sally Frautschy, Gregory Cole, Donna Masterman, Jeffrey Cummings

Institution: University of California, Los Angeles

Language: English

Topic: Curcumin's Biomedical Applications

Subfield: Molecular Medicine

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institute on Aging, National Institute of Neurological Disorders and Stroke