Work

Pediatric T‐cell post‐transplant lymphoproliferative disorder after solid organ transplantation

Year: 2006

Type: article

Abstract: Post-transplant lymphoproliferative disorder (PTLD) is the most common treatment related malignancy that occurs after solid organ transplantation (SOT). PTLD has extended from its initial description as an Epstein-Barr virus (EBV)-driven B-cell proliferation to include EBV-negative and non B-lineage cases. T-cell PTLD (T-PTLD) is rare in both adults and children. We report two cases of pediatric T-PTLD after SOT (liver and lungs) and review cases reported in the literature. Both patients had a bimodal response to therapy with initial eradication of bulky nodal disease with regimens typically used to treat leukemia, but persistence of low-level clonal T-cells in marrow, CSF and lung in one case.

Source: Pediatric Blood & Cancer

DOI: 10.1002/pbc.21072

Authors: Fan Yang, Ying Li, Raul Braylan, Stephen P. Hunger, Li‐Jun Yang

Institutions: University of Florida, UF Health Cancer Center, University of Florida Health

Language: English

Topic: Viral-associated cancers and disorders

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases