Peptide Receptor Radionuclide Therapy: Pre-clinical studies
Year: 2001
Type: dissertation
Abstract: The aims of this thesis were to investigate the possibilities of antitumour treatment with \\noctreotide and peptide receptor radionuclide therapy with radiolabelled octreotide in the rat. Therefore \\nwe used a liver metastases model with somatostatin receptor-positive and somatostatin receptornegative \\ntumours. We also studied the tumour growth stimulating effect of liver regeneration after \\npartial hepatectomy. Since, if this putative tumour growth stimulation by partial hepatectomy could be \\ndemonstrated we wanted to see if treatment with octreotide and radionuclide therapy could be \\neffective also after partial hepatectomy and whether this treatment would subsequently influence liver \\nregeneration. In addition we wanted to investigate the value of somatostatin receptor scintigraphy in \\npatients with liver metastases of neuroendocrine tumours to define patients that could possibly benefit \\nfrom peptide receptor radionuclide therapy.
Author: Gerrit D. Slooter
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2157138278