Approaches for quantifying energy intake and %calorie restriction during calorie restriction interventions in humans: the multicenter CALERIE study
Year: 2011
Type: article
Abstract: Calorie restriction (CR) is a component of most weight loss interventions and a potential strategy to slow aging. Accurate determination of energy intake and %CR is critical when interpreting the results of CR interventions; this is most accurately achieved using the doubly labeled water method to quantify total energy expenditure (TEE). However, the costs and analytical requirements of this method preclude its repeated use in many clinical trials. Our aims were to determine 1) the optimal TEE assessment time points for quantifying average energy intake and %CR during long-term CR interventions and 2) the optimal approach for quantifying short-term changes in body energy stores to determine energy intake and %CR during 2-wk DLW periods. Adults randomized to a CR intervention in the multicenter CALERIE study underwent measurements of TEE by doubly labeled water and body composition at baseline and months 1, 3, and 6. Average %CR achieved during the intervention was 24.9 ± 8.7%, which was computed using an approach that included four TEE assessment time points (i.e., TEE(baseline, months 1, 3, and 6)) plus the 6-mo change in body composition. Approaches that included fewer TEE assessments yielded %CR values of 23.4 ± 9.0 (TEE(baseline,) months 3 and 6), 25.0 ± 8.7 (TEE(baseline,) months 1 and 6), and 20.9 ± 7.1% (TEE(baseline, month 6)); the latter approach differed significantly from approach 1 (P < 0.001). TEE declined 9.6 ± 9.9% within 2-4 wk of CR beginning and then stabilized. Regression of daily home weights provided the most reliable estimate of short-term change in energy stores. In summary, optimal quantification of energy intake and %CR during weight loss necessitates a TEE measurement within the first month of CR to capture the rapid reduction in TEE.
Authors: Susan B. Racette, Sai Krupa Das, Manjushri Bhapkar, Evan C. Hadley, Susan B. Roberts, Eric Ravussin, Carl Pieper, James P. DeLany, William E. Kraus, James Rochon, Leanne M. Redman, The CALERIE Study Group
Language: English
Topic: Dietary Effects on Health
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: National Institutes of Health, National Institute on Aging, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Research Resources, National Center for Advancing Translational Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: G1004446241, G151374072, Metabolic Adaptations to Two Year Caloric Restriction, Caloric Restriction and Aging in Humans, Diabetes Research & Training Center, G2337220457, G236705245, G246532802, G5781986915, Effects of weight and insulin sensitivity on reproductive function in PCOS, G770793272, G77486010, G799249705, Dietary Energy Restriction and Metabolic Aging in Humans, CALERIE Competitive Renewal, Washington University Nutrition Obesity Research Center, Pennington/Louisiana NORC, GENERAL CLINICAL RESEARCH CENTER
OpenAlex ID: W2157176827