Year: 2003
Type: review
Abstract: Nonstandard abbreviations used: methicillin-resistant Staphylococcus aureus (MRSA); staphylococcal cassette chromosome mec (SCCmec); methicillin-susceptible S. aureus (MSSA); penicillin-binding protein (PBP); quinolone resistance-determining region (QRDR); minimal inhibitory concentration (MIC); vancomycin intermediate-resistant S. aureus (VISA); vancomycin-resistant S. aureus (VRSA). SCIENCE IN MEDICINEFigure 1 S. aureus infections in intensive care units in the National Nosocomial Infections Surveillance System.Data include the total number of infections from 1987 to 1997.Isolates were tested for sensitivity to the following antimicrobial agents: gentamicin, tobramycin, amikacin, ciprofloxacin, clindamycin, erythromycin, chloramphenicol, trimethoprim-sulfamethoxazole, and vancomycin.Some hospitals did not test for all of the antibiotics.Reproduced with permission from New England Journal of Medicine (4).A Examples of several of the S. aureus mechanisms of resistance to selected antibiotics (77, 95-97).Pl, plasmid; C, chromosome; Tn, transposon; QRDR, quinolone resistance-determining region.
DOI: 10.1172/jci18535
Author: Franklin D. Lowy
Institution: Columbia University
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2157177676