Work

The Fat and Warts signaling pathways: new insights into their regulation,mechanism and conservation

Year: 2008

Type: review

Abstract: A cassette of cytoplasmic Drosophila tumor suppressors, including the kinases Hippo and Warts, has recently been linked to the transmembrane tumor suppressor Fat. These proteins act within interconnected signaling pathways, the principal functions of which are to control the growth and polarity of developing tissues. Recent studies have enhanced our understanding of the basis for signal transduction by Fat and Warts pathways, including the identification of a DNA-binding protein at the end of the pathway, have established the conservation of Fat and Warts signaling from flies to mammals, and have given us new insights into their regulation and biological functions.

Source: Development

DOI: 10.1242/dev.020974

Authors: B. V. V. G. Reddy, Kenneth D. Irvine

Institutions: Rutgers, The State University of New Jersey, Howard Hughes Medical Institute

Language: English

Topic: Hippo pathway signaling and YAP/TAZ

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funders: Howard Hughes Medical Institute, National Institute of General Medical Sciences

Award: Growth regulation by the Fat signaling pathway