Work

Conversion of neurons and glia to external-cell fates in the external sensory organs of Drosophila hamlet mutants by a cousin-cousin cell-type respecification

Year: 2004

Type: preprint

Abstract: The Drosophila external sensory organ forms in a lineage elaborating from a single precursor cell via a stereotypical series of asymmetric divisions. HAMLET transcription factor expression demarcates the lineage branch that generates two internal cell types, the external sensory neuron and thecogen. In HAMLET mutant organs, these internal cells are converted to external cells via an unprecedented cousin-cousin cell-fate respecification event. Conversely, ectopic HAMLET expression in the external cell branch leads to internal cell production. The fate-determining signals NOTCH and PAX2 act at multiple stages of lineage elaboration and HAMLET acts to modulate their activity in a branch-specific manner.

Source: Genes & Development

DOI: 10.1101/gad.1170904

Authors: Adrian W. Moore, Fabrice Roegiers, Lily Y. Jan, Yuh-Nung Jan

Institutions: Howard Hughes Medical Institute, University of California, San Francisco

Language: English

Topic: Developmental Biology and Gene Regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funders: Howard Hughes Medical Institute, Wellcome Trust, National Institutes of Health, National Institute of Neurological Disorders and Stroke

Awards: Genetic Dissection of Dendrite Development, G9000342840