Work

Hidden Dangers: A Cryptic Exon Disrupts BRCA2 mRNA

Year: 2012

Type: article

Abstract: The first mutation that disrupts BRCA2 mRNA by including a novel, cryptic exon is reported in this issue. The mutation lies deep within an intron and would not have been detected by conventional screening methods. In the future, more mutations may be discovered by direct mRNA analysis.

Source: Clinical Cancer Research

DOI: 10.1158/1078-0432.ccr-12-2090

Authors: James D. Fackenthal, Younghee Lee, Olufunmilayo I. Olopade

Institution: University of Chicago Medical Center

Language: English

Topic: BRCA gene mutations in cancer

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Cancer Institute