Work

Infrequent Occurrence of Natural Mutations in the pp65495–503Epitope Sequence Presented by the HLA A∗0201 Allele among Human Cytomegalovirus Isolates

Year: 2001

Type: article

Abstract: To determine if mutations of an immunodominant HLA-restricted cytomegalovirus (CMV) peptide sequence occur in nature, the sequence corresponding to the HLA A*0201-specific peptide CMVpp65(495-503) was determined in 50 human CMV isolates. Rare mutations were detected; 6 of 50 were silent mutations at the amino terminus of the peptide, while 3 of 50 were mutations of the native methionine residue to isoleucine (M499I). The observed M499I mutation in three isolates decreased cytolytic targeting.

Source: Journal of Virology

DOI: 10.1128/jvi.75.5.2472-2474.2001