Work

Efficacy of Ambruticin Analogs in a Murine Model of Invasive Pulmonary Aspergillosis

Year: 2006

Type: article

Abstract: Ambruticins are a family of polyketides. The antifungal activity of an ambruticin, KOSN-2079, was tested in the mouse model of invasive aspergillosis. KOSN-2079 significantly reduced pulmonary fungal burdens and improved survival over that with the vehicle control. These results support the continued development of ambruticins as antifungal agents.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.00558-06

Authors: Lisa Y. Chiang, Daniele E. Ejzykowicz, Zong-Qiang Tian, Leonard Katz, Scott G. Filler

Institutions: The Lundquist Institute, Harbor–UCLA Medical Center, Kosan Biosciences (United States), University of California, Los Angeles

Language: English

Topic: Antifungal resistance and susceptibility

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: American Heart Association, National Institutes of Health, National Institute of Allergy and Infectious Diseases