Year: 2011
Type: dissertation
Abstract: Transthyretin (TTR) is a tetrameric protein involved in the extracellular transport of various compounds including thyroid hormones and retinol (vitamin A).Misfolded and aggregated TTRs (agTTR) contribute to amyloidogenic diseases such as senile systemic amyloidosis and familial amyloid polyneuropathy which are characterized by extracellular deposition of transthyretin-containing amyloid fibrils.The main objective of this thesis project was to examine the cellular toxicity of agTTR as it relates to amyloidogenic disease.Novel evidence is pathway that is different from the well-established clathrin-mediated endocytosis of Tf, and likely represents a caveolar endocytic pathway.Moreover, through chemical crossslinking and ligand blotting experiments, evidence was obtained for a novel somatic cell membrane TTR receptor.
Source: Summit (Simon Fraser University)
Author: Vai Hong Fong
Language: English
Subfield: Internal Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2157441037