Work

Correlation of clinical and immunological data in a metastatic melanoma patient with heterogeneous tumor responses to ipilimumab therapy.

Year: 2010

Type: article

Abstract: Melanoma patients treated with anti-CTLA-4 have shown a range of anti-tumor responses. In this report, we describe the response of a single patient to anti-CTLA-4, with individual lesions disappearing, others stabilizing, and others progressing. These responses can be viewed as a clear manifestation of cancer immunoediting and its three phases of elimination, equilibrium and escape, with each tumor in this patient being at a discrete stage in the process. The patient's course and associated immunological monitoring and other laboratory data are presented in an immunogram, a way to visualize temporal associations between the multiple clinical and laboratory parameters.

Source: PubMed

Authors: Jianda Yuan, David B Page, Geoffrey Y Ku, Yanyun Li, Zhenyu Mu, Charlotte Ariyan, Humilidad F Gallardo, Ruth-Ann Roman, Agnes I Heine, Stephanie L Terzulli, Erika Ritter, Sacha Gnjatic, Gerd Ritter, Achim A Jungbluth, James P Allison, Lloyd J Old, Jedd D Wolchok

Language: English

Topic: Cancer Immunotherapy and Biomarkers

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institutes of Health

Awards: MSKCC Research Center for Botanical Immunomodulators, Targeted antigen receptor treatment of cancer

OpenAlex ID: W2157545090

FWCI: 2.845

Cites: 31

Cited by: 46

Related to: 20