[O1‐04‐05]: Subgroups of Alzheimer disease based on cerebrospinal fluid levels of molecular markers
Year: 2005
Type: article
Study design: Observational Study
Abstract: Alzheimer disease, the most common cause of dementia, is both polyetiological and heterogeneous, and its clinical diagnosis remains probable, to date. We postulated that more than one disease mechanism might be involved in producing the Alzheimer histopathology and that various subgroups of the disease might be identified based on the CSF levels of the proteins associated with senile (neuritic) plaques and neurofibrillary tangles, the two histopathological hallmarks of the disease. We immunoassayed the levels of tau, ubiquitin and Aβ1–42 in retrospectively collected CSFs of 468 patients clinically diagnosed as Alzheimer disease (353 CSFs) and as non-Alzheimer neurological or non-neurological cases (115 CSFs), and based on the levels of these molecular markers, all subjects were subjected to latent profile analysis to determine the assignment of each subject to a particular cluster. We found that Alzheimer disease subdivided into at least five subgroups based on the CSF levels of Aβ1–42, tau and ubiquitin, and that each subgroup presented a different clinical profile. Alzheimer disease appears to be a family of closely related disorders which subdivides into at least five subgroups. Each of these subgroups, which can be identified by the CSF analysis, might benefit differently from different therapeutic drugs.
Source: Alzheimer s & Dementia
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2157600004