Work

Venezuelan Equine Encephalomyelitis Virus Structure and Its Divergence from Old World Alphaviruses

Year: 2001

Type: article

Abstract: Although alphaviruses have been extensively studied as model systems for the structural organization of enveloped viruses, no structures exist for the phylogenetically distinct eastern equine encephalomyelitis (EEE)-Venezuelan equine encephalomyelitis (VEE) lineage of New World alphaviruses. Here we report the 25-A structure of VEE virus, obtained from electron cryomicroscopy and image reconstruction. The envelope spike glycoproteins of VEE virus have a T=4 icosahedral arrangement, similar to that observed in Old World Sindbis, Semliki Forest, and Ross River alphaviruses. However, VEE virus has pronounced differences in its nucleocapsid structure relative to nucleocapsid structures repeatedly observed in Old World alphaviruses.

Source: Journal of Virology

DOI: 10.1128/jvi.75.19.9532-9537.2001

Authors: Angel Paredes, Kathy Alwell-Warda, Scott C. Weaver, Wah Chiu, Stanley J. Watowich

Institutions: Baylor College of Medicine, The University of Texas Medical Branch at Galveston

Language: English

Topic: Mosquito-borne diseases and control

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

Open Access status: green

Funders: U.S. Public Health Service, National Institute of Allergy and Infectious Diseases

Awards: G1030713940, G3399561052, G5267682530