Work

Identification of Antioxidants from Sequence Information Using Naïve Bayes

Year: 2013

Type: article

Abstract: Antioxidant proteins are substances that protect cells from the damage caused by free radicals. Accurate identification of new antioxidant proteins is important in understanding their roles in delaying aging. Therefore, it is highly desirable to develop computational methods to identify antioxidant proteins. In this study, a Naïve Bayes-based method was proposed to predict antioxidant proteins using amino acid compositions and dipeptide compositions. In order to remove redundant information, a novel feature selection technique was employed to single out optimized features. In the jackknife test, the proposed method achieved an accuracy of 66.88% for the discrimination between antioxidant and nonantioxidant proteins, which is superior to that of other state-of-the-art classifiers. These results suggest that the proposed method could be an effective and promising high-throughput method for antioxidant protein identification.

Source: Computational and Mathematical Methods in Medicine

DOI: 10.1155/2013/567529

Authors: Peng-Mian Feng, Hao Lin, Wei Chen

Institutions: North China University of Science and Technology, University of Electronic Science and Technology of China

Language: English

Topic: Machine Learning in Bioinformatics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $2,550