Year: 2012
Type: article
Abstract: The letter by Bergmann and collaborators 1 questions our comments 2 regarding their work on 14 C birth dating of human cardiomyocytes with aging.3 Three points are made in an attempt to challenge the issues we have raised, which cast serious doubts on the validity of their data on myocyte turnover with physiological aging: (1) appropriateness of the myocardial samples examined; (2) specificity of the protocol used for the isolation of myocyte nuclei; and (3) correct interpretation of the 14 C measurements.
Source: Circulation Research
Institutions: Brigham and Women's Hospital, Harvard University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: bronze
Awards: Repair and Angiogenesis by Stem Cells in Human Heart, G1579596718, Redefining Human Myocardial Biology, G3425638684, G3657486565, Cardiac Stem Cells and Diabetic Cardiomyopathy, Isolation and culture of c-kit-positive human cardiac stem cells (CSCs): Aiming for the first clinical trial in Japan, G5061682936, G5080006649, Cardiomyogenesis in the Adult Heart, G600265253, Aging and Homeostasis of Cardiac Stem Cell Niches, IGF-1, Gender, Heart Failure and Longevity: A Paradigm Shift, G640502336, Telomeric Shortening, p53 and miR-34a Condition Senescence of Cardiac Progenitors, Stem Cells in the Developing Heart, G7500434723
OpenAlex ID: W2157693942