Work

Enantioselective Total Synthesis and Studies into the Configurational Stability of Bismurrayaquinone A

Year: 2011

Type: article

Abstract: Lost in rotation: the concise strategy of the first enantioselective total synthesis of bismurrayaquinone A utilized traceless stereochemical exchange to form an enantioenriched biphenyl core that was elaborated in a bidirectional manner to the natural product. Observed racemization on an unsuccessful initial route prompted studies into the configurational stability of bismurrayaquinone A and related biquinones.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.201104726

Authors: Leah C. Konkol, Fenghai Guo, Amy A. Sarjeant, Regan J. Thomson

Institution: Northwestern University

Language: English

Topic: Axial and Atropisomeric Chirality Synthesis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funder: National Institute of General Medical Sciences

Award: New Methods for the Concise Synthesis of Bioactive Polycyclic Molecules