Work

Prostate Carcinoma Metastatic to the Stomach: Report of Two Cases and Review of the Literature

Year: 2010

Type: article

Abstract: ReportPr ostate carcinoma is one of the most frequently diagnosed malignancies in men. 1 Common sites of metastasis include the lymph nodes and bone; rarely has metastatic prostate carcinoma been reported to involve the stomach [2][3][4][5][6][7][8] or other sites of the upper gastrointestinal tract.[9][10][11][12] Here we describe two unusual cases of prostate carcinoma metastatic to the stomach. Case 1An 89-year-old Caucasian man presented with declining health, weakness, nausea, vomiting, and decreased appetite.Comorbidities included hypertension, history of colon polyps, total colectomy following gastrointestinal bleed postcolonoscopy, congestive heart failure, aortic valve replacement, coronary artery disease, and congestive obstructive pulmonary disease.The patient had a 15-year history of elevated and rising prostatic specific antigen (PSA).His PSA a year before presentation was 1565 units.Family history was significant for a brother with prostate carcinoma.The conservative course of annual follow-up had been decided due to the patient's advanced age, two negative prostate biopsies, and lack of symptoms.At the time of presentation the patient's physical health had deteriorated to the extent that he was unable to live independently and had moved into an assisted living facility.Central to the evaluation of his illness, an esophagogastroduodenal endoscopy showed a poorly distensible stomach with prominent rugal folds and ulcerations distal to the gastroesophageal junction and along the lesser curvature.Due to the markedly elevated serum PSA of 1660 units, the case was discussed with the pathologist.The gastric biopsy (figure 1A) revealed the lamina propria to harbor

Source: Clinical Medicine & Research

DOI: 10.3121/cmr.2010.855

Authors: A. A. Onitilo, J. M. Engel, J. M. Resnick

Institutions: Marshfield Clinic Weston Center, Marshfield Clinic, Marshfield Clinic, Marshfield Clinic

Language: English

Topic: Metastasis and carcinoma case studies

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2157857039