Human Papillomaviruses Modulate MicroRNA 145 Expression To Directly Control Genome Amplification
Year: 2013
Type: article
Abstract: Human papillomaviruses (HPVs) modulate expression of host microRNAs. Our deep-sequencing analysis of organotypic raft cultures identified microRNA 145 (miR-145) as a differentiation-dependent microRNA that has functionally active target sequences in the HPV-31 E1 and E2 open reading frames. Overexpression of miR-145 in HPV-positive cells resulted in reduced genome amplification and late gene expression, along with decreased levels of cellular transcription factor KLF-4. Our studies show that HPV modulates miR-145 expression to control its own life cycle.
Source: Journal of Virology
DOI: 10.1128/jvi.00153-13
Authors: Vignesh Gunasekharan, Laimonis A. Laimins
Institution: Northwestern University
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2157930304