Work

Selective Vaporization of Superheated Nanodroplets for Rapid, Sensitive, Acoustic Biosensing

Year: 2015

Type: article

Abstract: Superheated perfluorocarbon nano-droplets exhibit promise as sensitive acoustic biosensors. Aggregation of biotin-decorated lipid-shelled droplets by streptavidin greatly increases the yield of bubbles formed by ultrasound-induced vaporization. Streptavidin is sensed down to 1 × 10(-13) m, with differentiable signal appearing in as little as two minutes, using a scalable assay without washing, processing, or development steps.

Source: Advanced Healthcare Materials

DOI: 10.1002/adhm.201500315

Authors: Rajarshi Chattaraj, Praveena Mohan, Jeremy D. Besmer, Andrew P. Goodwin

Institution: University of Colorado Boulder

Language: English

Topic: Ultrasound and Hyperthermia Applications

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: green

Funders: National Institutes of Health, National Cancer Institute, National Institute of Biomedical Imaging and Bioengineering, National Center for Chronic Disease Prevention and Health Promotion

Awards: Targeted Microbubbles for Noninvasive Measurement of Tumor VEGF Levels, G3555707836, Rapid, Multiscale Sensing Using Acoustic Detection Mechanisms, Enzyme-Responsive Nanoemulsions as Tumor-Specific Ultrasound Contrast Agents