Work

Evidence that Electrostatic Interactions Dictate the Ligand‐Induced Arrest of RNA Global Flexibility

Year: 2005

Type: article

Abstract: The global dynamics of the TAR RNA from HIV-1 bound to two distinctly charged molecules have been characterized by NMR studies of residual dipolar couplings (see picture). While neomycin B (NeoB: +5) arrests global motions in TAR, the small organic molecule acetylpromazine (AcP: +1) does not. Results indicate that electrostatic interactions are critical for arresting global motions in RNA.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.200500075

Authors: Stephen W. Pitt, Qi Zhang, Dinshaw J. Patel, Hashim M. Al‐Hashimi

Institutions: Cornell University, Weill Cornell Medicine, University of Michigan, Memorial Sloan Kettering Cancer Center

Language: English

Topic: RNA and protein synthesis mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: National Institutes of Health, National Cancer Institute, National Institute of General Medical Sciences

Awards: ANTITUMOR DRUG DNA AND DNA APTAMER COMPLEXES IN SOLUTION, G6983792853, DNA/RNA G-Quadruplexes: Structures, Transitions and Recognition, Cancer Center Support Grant