p53 connects tumorigenesis and reprogramming to pluripotency
Year: 2010
Type: article
Abstract: The tumor suppressor gene p53 prevents the initiation of tumor formation by inducing cell cycle arrest, senescence, DNA repair, and apoptosis. Recently, the absence or mutation of p53 was described to facilitate nuclear reprogramming. These findings suggest an influence of p53 on the de-differentiation process, and highlight the similarities between induction of pluripotency and tumor formation.
DOI: 10.1084/jem.20101866
Authors: Natalia Tapia, Hans R. Schöler
Institution: Max Planck Institute for Molecular Biomedicine
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2158144966