Association of polymorphisms in the FOXO1 and UCP3 genes with nonalcoholic fatty liver disease in Chinese children
Year: 2013
Type: article
Study design: Observational Study
Abstract: We genotyped nine single nucleotide polymorphisms (SNPs) for association analyses in children (250 patients with NAFLD, 111 patients with metabolic sydrome, 146 with obese and 200 controls). Body mass index (BMI), waist and hip circumference, blood pressure, fasting blood glucose (FBG), insulin (FIN), lipid profiles were measured and performed B-ultrasound examination in all the subjects. In the NAFLD group, FOXO1A and UCP3 allele were significantly more frequent in both association studies. There was a significant difference in the overall distribution of the genotype frequencies (UCP3 rs11235972, rs6195, rs1800849), (FOXO1 rs2721068), and there was a significant difference (P = 0.0298, 0.0191) in the distribution of the haplotype (UCP3 rs11235972, UCP3 rs1800849), might be good NAFLD markers. In conclusion, our study suggests a effect of UCP3 haplotype on NAFLD development and relevant intermediate phenotypes which predispose for NAFLD.
Authors: Yan-ping Xu, Li Liang, Chun-lin Wang
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,790
OpenAlex ID: W2158299628