Year: 2006
Type: article
Study designs: Systematic Review, Meta-Analysis
Abstract: Lung cancer is the most common malignancy in the Western world, and the main risk factor is tobacco smoking. Polymorphisms in metabolic genes may modulate the risk associated with environmental factors. The glutathione S-transferase theta 1 gene (GSTT1) is a particularly attractive candidate for lung cancer susceptibility because of its involvement in the metabolism of polycyclic aromatic hydrocarbons found in tobacco smoke and of other chemicals, pesticides, and industrial solvents. The frequency of the GSTT1 null genotype is lower among Caucasians (10-20%) than among Asians (50-60%). The authors present a meta- and a pooled analysis of case-control, genotype-based studies that examined the association between GSTT1 and lung cancer (34 studies, 7,629 cases and 10,087 controls for the meta-analysis; 34 studies, 7,044 cases and 10,000 controls for the pooled analysis). No association was observed between GSTT1 deletion and lung cancer for Caucasians (odds ratio (OR) = 0.99, 95% confidence interval (CI): 0.87, 1.12); for Asians, a positive association was found (OR = 1.28, 95% CI: 1.10, 1.49). In the pooled analysis, the odds ratios were not significant for either Asians (OR = 0.97, 95% CI: 0.83, 1.13) or Caucasians (OR = 1.09, 95% CI: 0.99, 1.21). No significant interaction was observed between GSTT1 and smoking on lung cancer, whereas GSTT1 appeared to modulate occupational-related lung cancer.
Source: American Journal of Epidemiology
DOI: 10.1093/aje/kwj321
Authors: S Raimondi, V Paracchini, H Autrup, J. Barros-Dios, S Benhamou, P Boffetta, M. Cote, I. Dialyna, V Dolzan, R Filiberti, S Garte, A Hirvonen, K Husgafvel-Pursiainen, E. Imyanitov, I Kalina, D Kang, C Kiyohara, T Kohno, P Kremers, Q Lan, S London, A. Povey, A Rannug, E Reszka, A Risch, M Romkes, J Schneider, A Seow, P. Shields, R. Sobti, M Sorensen, M Spinola, M. Spitz, R. Strange, I Stucker, H Sugimura, J To-Figueras, S Tokudome, P Yang, J-M Yuan, M Warholm, E Taioli
Institutions: Aarhus University, Universidade de Santiago de Compostela, Inserm, Centre international de recherche sur le cancer, Wayne State University, The Barbara Ann Karmanos Cancer Institute, University of Crete, University of Ljubljana, University of Pittsburgh, Finnish Institute of Occupational Health, Institute of Oncology NN Petrov, University of Pavol Jozef Šafárik, Seoul National University, Kyushu University, National Cancer Centre Japan, University of Liège, National Cancer Institute, Division of Cancer Epidemiology and Genetics, National Institute of Environmental Health Sciences, University of Manchester, Karolinska Institutet, Nofer Institute of Occupational Medicine, German Cancer Research Center, Justus-Liebig-Universität Gießen, National University of Singapore, Georgetown University Medical Center, Panjab University, Danish Cancer Society, Fondazione IRCCS Istituto Nazionale dei Tumori, The University of Texas MD Anderson Cancer Center, Keele University, Hamamatsu University School of Medicine, Hospital Clínic de Barcelona, Nagoya City University, Mayo Clinic, University of Minnesota
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: bronze
Funder: National Cancer Institute
OpenAlex ID: W2158310447