Work

Association between Cellular Immune Activation, Target Cell Frequency, and Risk of Human Immunodeficiency Virus Type 1 Superinfection

Year: 2014

Type: article

Study design: Observational Study

Abstract: We performed a case-control study of women at risk of HIV-1 superinfection to understand the relationship between immune activation and HIV-1 acquisition. An increase in the frequency of HIV-1 target cells, but not in other markers of T cell activation, was associated with a 1.7-fold increase in the odds of superinfection. This suggests that HIV-1 acquisition risk is influenced more by the frequency of target cells than by the generalized level of immune activation.

Source: Journal of Virology

DOI: 10.1128/jvi.00187-14

Authors: Catherine A. Blish, Ozge C. Dogan, Walter Jaoko, R. Scott McClelland, Kishorchandra Mandaliya, Katherine Odem-Davis, Barbra A. Richardson, Julie Overbaugh

Institutions: University of Washington, Fred Hutch Cancer Center, University of Nairobi

Language: English

Topic: HIV Research and Treatment

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: University of Washington, Institute of Translational Health Sciences, Georgia Clinical and Translational Science Alliance, National Institutes of Health, Center for AIDS Research, University of Washington, National Institute of Allergy and Infectious Diseases, National Center for Research Resources, National Center for Advancing Translational Sciences

Awards: Early and Reinfection in High Risk Women, Institute of Translational Health Sciences, Institute for Translational Health Science (UL1), Defining Immune Deficits in HIV-1 Infected Women, University of Washington/Fred Hutch Center for AIDS Research

OpenAlex ID: W2158320458

FWCI: 0.594

Cites: 45

Cited by: 4

Related to: 10