Correlation of structure with T cell responses of the three members of the HLA-DRw52 allelic series.
Year: 1989
Type: article
Abstract: A third allele at the DRB3 locus, DRw52c, represents an intermediate sequence between DRw52a and DRw52b and may have arisen by a gene conversion-like event. The recognition of cells bearing these molecules by a number of alloreactive and antigen-specific DR-restricted T cell clones was analyzed. On the basis of a theoretical model of HLA class II structure, distinct amino acid clusters have been identified as motifs controlling TCR recognition. These are located both in the cleft and in the alpha-helical edge of the MHC class II recognition platform. Motifs shared between two alleles may restrict public T cell clones.
Institution: University of Geneva
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
Awards: G1955217443, G235421114, G2597936294
OpenAlex ID: W2158356438