Effect of Diabetes and Insulin on the Maximum Capacity of the Renal Tubules to Reabsorb Glucose 1
Year: 1951
Type: article
Abstract: Glycosuria occurs whenever the amount of glu- cose filtered by the glomeruli exceeds the reab- sorptive capacity of the tubules.The glycosuria of diabetes, therefore, is dependent not only on the degree of hyperglycemia but also on the concur- rent glucose reabsorptive capacity.A number of observers have noted that diabetic patients sometimes may have little or no glyco- suria in spite of hyperglycemia (1,2).Mirsky and Nelson (2) have attributed this phenomenon to decreased glomerular filtration rate, especially among elderly patients, or to an increase in the glucose reabsorptive capacity of the tubules.Glucose reabsorption depends on an active trans- port system which is undoubtedly enzymatic in na-
DOI: 10.1172/jci102424
Institution: New York University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W2158482469