Plasma 25-hydroxyvitamin D and colorectal cancer risk according to tumour immunity status
Year: 2015
Type: article
Study design: Observational Study
Abstract: OBJECTIVE: Evidence suggests protective effects of vitamin D and antitumour immunity on colorectal cancer risk. Immune cells in tumour microenvironment can convert 25-hydroxyvitamin D [25(OH)D] to bioactive 1α,25-dihydroxyvitamin D3, which influences neoplastic and immune cells as an autocrine and paracrine factor. Thus, we hypothesised that the inverse association between vitamin D and colorectal cancer risk might be stronger for cancers with high-level immune response than those with low-level immune response. DESIGN: We designed a nested case-control study (318 rectal and colon carcinoma cases and 624 matched controls) within the Nurses' Health Study and Health Professionals Follow-up Study using molecular pathological epidemiology database. Multivariable conditional logistic regression was used to assess the association of plasma 25(OH)D with tumour subtypes according to the degree of lymphocytic reaction, tumour-infiltrating T cells (CD3+, CD8+, CD45RO+ (PTPRC) and FOXP3+ cells), microsatellite instability or CpG island methylator phenotype. RESULTS: The association of plasma 25(OH)D with colorectal carcinoma differed by the degree of intratumoural periglandular reaction (p for heterogeneity=0.001); high 25(OH)D was associated with lower risk of tumour with high-level reaction (comparing the highest versus lowest tertile: OR 0.10; 95% CI 0.03 to 0.35; p for trend<0.001), but not risk of tumour with lower-level reaction (p for trend>0.50). A statistically non-significant difference was observed for the associations of 25(OH)D with tumour subtypes according to CD3+ T cell density (p for heterogeneity=0.03; adjusted statistical significance level of α=0.006). CONCLUSIONS: High plasma 25(OH)D level is associated with lower risk of colorectal cancer with intense immune reaction, supporting a role of vitamin D in cancer immunoprevention through tumour-host interaction.
Source: Gut
Language: English
Topic: Vitamin D Research Studies
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: Dana Farber/ Harvard Cancer Center SPORE in Gastrointestinal Cancer, G1828895303, Epigenetic Events and Colorectal Cancer Epidemiology, Dietary And Lifestyle Determinants Of Colon Cancer Recurrence and Survival, Biochemical Markers in the nurses' Health Study Cohort, Inflammation and Colorectal Neoplasia, G361298724, Dietary and Hormonal Determinants of Cancer in Women, Role of Vitamin D, Inflammation, and Energy Balance in Colorectal Cancer Survival, Impact of Celecoxib and Inflammation on Survival in Stage III Colon Cancer, G459566519, Mentored Patient-Oriented Research in Digestive Diseases, Prospective Studies of Diet and Cancer in Men and Women, Long Term Multidisciplinary Study of Cancer in Women: The Nurses Health Study, Cancer Epidemiology Cohort in Male Health Professionals, Lifestyle, genetics and colonoscopy for colorectal cancer prevention, Calcium Intake and Colorectal Cancer Incidence and Survival, G885693336, Cancer Epidemiology Cohort in Male Health Professionals
OpenAlex ID: W2158528533