Work

A Chemical Epitope‐Targeting Strategy for Protein Capture Agents: The Serine 474 Epitope of the Kinase Akt2

Year: 2013

Type: article

Abstract: Target and click: Peptide ligands targeted to the C-terminal motif of the kinase Akt2 were obtained by combining phosphate recognition of a dinuclear zinc(II) complex with in situ click chemistry to target this epitope. The peptide ligands (shown as XXXXX) selectively bind the C-terminal polypeptide of Akt2, and are selective for Akt2 relative to the Akt1 and Akt3 isoforms. The ligands differentially modulate Akt2 activity.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.201305882

Authors: Arundhati Nag, Samir Das, Mary Beth Yu, Kaycie M. Deyle, Steven W. Millward, James R. Heath

Institutions: California Institute of Technology, The University of Texas MD Anderson Cancer Center

Language: English

Topic: Click Chemistry and Applications

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze