Work

Non-micro-short RNAs: the new kids on the block

Year: 2012

Type: article

Abstract: The advent of ultra-high-throughput sequencing has led to the discovery of a large group of small, noncoding RNAs that are not microRNAs. The functional relevance of microRNAs has been well established over the last decade. In this Perspective, we focus on the non-micro-short RNAs that comprise a variety of functional classes and range from 16-40 nucleotides in size. We will highlight how some of these non-micro-short RNAs were discovered, as well as their biogenesis, potential mechanisms of action, and role in diverse biological processes, development, and disease. Finally, we will describe what must be done to further our understanding of these enigmatic molecules.

Source: Molecular Biology of the Cell

DOI: 10.1091/mbc.e12-10-0716

Authors: Bijan K. Dey, Adam C. Mueller, Anindya Dutta

Institution: University of Virginia

Language: English

Topic: Cancer-related molecular mechanisms research

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: National Cancer Institute, National Institute of Arthritis and Musculoskeletal and Skin Diseases

Awards: MicroRNAs in differentiation of muscle, University of Virginia Cancer Center Support Grant