Work

NEDD4: A Promising Target for Cancer Therapy

Year: 2014

Type: article

Abstract: The Neuronally expressed developmentally downregulated 4 (NEDD4), functioning largely as an E3 ubiquitin ligase, has been demonstrated to play a critical role in the development and progression of human cancers. In this review, to understand the regulatory mechanism(s) of NEDD4 as well as the signaling pathways controlled by NEDD4, we briefly describe the NEDD4 upstream regulators and its downstream ubiquitin substrates. Moreover, we further discuss its oncogenic roles in human malignancies. Therefore, targeting NEDD4 could be a potential therapeutic strategy for treatment of human cancers.

Source: Current Cancer Drug Targets

DOI: 10.2174/1568009614666140725092430

Authors: Xiantao Ye, Lixia Wang, Bingxue Shang, Zhiwei Wang, Wenyi Wei

Institutions: Soochow University, First Affiliated Hospital of Soochow University, Beth Israel Deaconess Medical Center, Harvard University

Language: English

Topic: Ubiquitin and proteasome pathways

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Cancer Institute, National Institute of General Medical Sciences