Radiogenomics: The Search for Genetic Predictors of Radiotherapy Response
Year: 2014
Type: review
Abstract: 'Radiogenomics' is the study of genetic variation associated with response to radiotherapy. Radiogenomics aims to uncover the genes and biologic pathways responsible for radiotherapy toxicity that could be targeted with radioprotective agents and; identify genetic markers that can be used in risk prediction models in the clinic. The long-term goal of the field is to develop single nucleotide polymorphism-based risk models that can be used to stratify patients to more precisely tailored radiotherapy protocols. The field has evolved over the last two decades in parallel with advances in genomics, moving from narrowly focused candidate gene studies to large, collaborative genome-wide association studies. Several confirmed genetic variants have been identified and the field is making progress toward clinical translation.
Source: Future Oncology
DOI: 10.2217/fon.14.173
Institutions: University of Rochester Medicine, University of Rochester, Icahn School of Medicine at Mount Sinai, Manchester Academic Health Science Centre, University of Manchester, The Christie Hospital, Aarhus University Hospital, University of Cambridge, Cambridge University Hospitals NHS Foundation Trust, University of Maryland, Baltimore, University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Addenbrooke's Hospital, Maastricht University Medical Centre, KU Leuven, University of Alberta, Cross Cancer Institute, University of Leicester, Universidade de Santiago de Compostela, Centre for Biomedical Network Research on Rare Diseases, Fundación Pública Galega de Medicina Xenómica, Servicio Gallego de Salud, NYU Langone Health, New York University
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2158907650