Year: 2010
Type: article
Abstract: Mathematics ability and disability is as heritable as other cognitive abilities and disabilities, however its genetic etiology has received relatively little attention. In our recent genome-wide association study of mathematical ability in 10-year-old children, 10 SNP associations were nominated from scans of pooled DNA and validated in an individually genotyped sample. In this paper, we use a 'SNP set' composite of these 10 SNPs to investigate gene-environment (GE) interaction, examining whether the association between the 10-SNP set and mathematical ability differs as a function of ten environmental measures in the home and school in a sample of 1888 children with complete data. We found two significant GE interactions for environmental measures in the home and the school both in the direction of the diathesis-stress type of GE interaction: The 10-SNP set was more strongly associated with mathematical ability in chaotic homes and when parents are negative.
Source: Behavior Genetics
Authors: Sophia J. Docherty, Yulia Kovas, Robert Plomin
Institution: King's College London
Language: English
Subfield: Statistics and Probability
Field: Mathematics
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $3,390
Awards: GENETICS OF GENERAL AND SPECIFIC MATH DISABILITIES, Multivariate genome-wide association study (GWAS) of reading and mathematics disabilities/abilities: A quantitative trait locus (QTL) perspective., G526448641, G5548061709, G6446382152, Mild mental impairment in children: Using large samples, DNA pooling and 100,000-SNP microarrays to detect QTLS of small effect size in systematic genome scan for allelic association, G8554707668
OpenAlex ID: W2158937019