Work

Convergence of Molecular, Modeling, and Systems Approaches for an Understanding of the Escherichia coli Heat Shock Response

Year: 2008

Type: review

Abstract: The heat shock response (HSR) is a homeostatic response that maintains the proper protein-folding environment in the cell. This response is universal, and many of its components are well conserved from bacteria to humans. In this review, we focus on the regulation of one of the most well-characterized HSRs, that of Escherichia coli. We show that even for this simple model organism, we still do not fully understand the central component of heat shock regulation, a chaperone-mediated negative feedback loop. In addition, we review other components that contribute to the regulation of the HSR in E. coli and discuss how these additional components contribute to regulation. Finally, we discuss recent genomic experiments that reveal additional functional aspects of the HSR.

Source: Microbiology and Molecular Biology Reviews

DOI: 10.1128/mmbr.00007-08

Authors: Eric Guisbert, Takashi Yura, Virgil A. Rhodius, Carol A. Gross

Institution: University of California, San Francisco

Language: English

Topic: Heat shock proteins research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: National Science Foundation, National Institutes of Health, National Institute of General Medical Sciences

Awards: G52781978, REGULATION OF THE HEAT SHOCK RESPONSE IN E. COLI, Regulation of the Heat Shock Response in E. Coli