Work

PRISM: a web server and repository for prediction of protein–protein interactions and modeling their 3D complexes

Year: 2014

Type: article

Abstract: The PRISM web server enables fast and accurate prediction of protein-protein interactions (PPIs). The prediction algorithm is knowledge-based. It combines structural similarity and accounts for evolutionary conservation in the template interfaces. The predicted models are stored in its repository. Given two protein structures, PRISM will provide a structural model of their complex if a matching template interface is available. Users can download the complex structure, retrieve the interface residues and visualize the complex model. The PRISM web server is user friendly, free and open to all users at http://cosbi.ku.edu.tr/prism.

Source: Nucleic Acids Research

DOI: 10.1093/nar/gku397

Authors: Alper Baspinar, Engin Cukuroglu, Ruth Nussinov, Ozlem Keskin, Attila Gursoy

Institutions: Koç University, Tel Aviv University, Frederick National Laboratory for Cancer Research, National Cancer Institute, Leidos Biomedical Research Inc. (United States)

Language: English

Topic: Protein Structure and Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $3,992

Funders: Türkiye Bilimsel ve Teknolojik Araştırma Kurumu, National Institutes of Health, U.S. Public Health Service, National Cancer Institute