Volumetric Correlates of Spatiotemporal Working and Recognition Memory Impairment in Aged Rhesus Monkeys
Year: 2010
Type: article
Abstract: Spatiotemporal and recognition memory are affected by aging in humans and macaque monkeys. To investigate whether these deficits are coupled with atrophy of memory-related brain regions, T(1)-weighted magnetic resonance images were acquired and volumes of the cerebrum, ventricles, prefrontal cortex (PFC), calcarine cortex, hippocampus, and striatum were quantified in young and aged rhesus monkeys. Subjects were tested on a spatiotemporal memory procedure (delayed response [DR]) that requires the integrity of the PFC and a medial temporal lobe-dependent recognition memory task (delayed nonmatching to sample [DNMS]). Region of interest analyses revealed that age inversely correlated with striatal, dorsolateral prefrontal cortex (dlPFC), and anterior cingulate cortex volumes. Hippocampal volume predicted acquisition of the DR task. Striatal volume correlated with DNMS acquisition, whereas total prefrontal gray matter, prefrontal white matter, and dlPFC volumes each predicted DNMS accuracy. A regional covariance analysis revealed that age-related volumetric changes could be captured in a distributed network that was coupled with declining performance across delays on the DNMS task. This volumetric analysis adds to growing evidence that cognitive aging in primates arises from region-specific morphometric alterations distributed across multiple memory-related brain systems, including subdivisions of the PFC.
Source: Cerebral Cortex
Authors: J. L. Shamy, C. Habeck, P. R. Hof, D. G. Amaral, S. G. Fong, M. H. Buonocore, Y. Stern, C. A. Barnes, P. R. Rapp
Language: English
Topic: Memory and Neural Mechanisms
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: bronze
Funders: Brain Research Foundation, McKnight Foundation, Evelyn F. McKnight Brain Research Foundation, National Institutes of Health, National Institute on Aging, National Institute of Mental Health, National Institute of Neurological Disorders and Stroke, National Institute of Biomedical Imaging and Bioengineering, National Center for Research Resources, California National Primate Research Center
Awards: California National Primate Research Center, G181457900, G1861218636, Multivariate approaches to neuroimaging analysis, G2312504923, G242163779, Center for Neural Systems of Fear & Anxiety, Functional Organization of the Hippocampal Formation, G3396533971, G3764580968, STRUCTURE ORGANIZATION OF MEMORY IN THE PRIMATE BRAIN, G443517899, G4944969212, G7987837039, HIPPOCAMPAL AND CORTICAL MEMORY STSYEMS, G8547547198, G9000043652, G9000055971, G9000222759, Cognition & Hippocampal/Cortical Systems in Aging
OpenAlex ID: W2158971044