Work

Prior Antibacterial Peptide-Mediated Inhibition of Protein Folding in Bacteria Mutes Resistance Enzymes

Year: 2006

Type: article

Abstract: The antimicrobial activity of amoxicillin against TEM-1-expressing strains could be fully recovered when bacteria were preincubated with sublethal doses of an antibacterial peptide derivative. Assays with the simultaneous administration of antibiotics or synergy assays with kanamycin or ciprofloxacin, where resistance development does not involve properly folded proteins, failed to yield similar results.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.00205-06

Authors: Laszlo Otvos, Vanessa de Olivier Inacio, John D. Wade, Predrag Cudic

Institutions: The Wistar Institute, Temple University, Florida Atlantic University, Florey Institute of Neuroscience and Mental Health

Language: English

Topic: Antibiotic Resistance in Bacteria

Subfield: Molecular Medicine

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2158988420

FWCI: 1.196

Cites: 30

Cited by: 21

Related to: 10