Ceacam1 Regulates Experimental Graft-Versus-Host-Disease
Year: 2009
Type: article
Abstract: Carcinoembryonic antigen associated cell adhesion molecule 1 (Ceacam1) is a type I transmembrane glycoprotein that regulates numerous processes including bacterial colonization of the gastrointestinal lumen and leukocyte function. Ceacam1 is expressed on gut epithelium and activated T cells, particularly in the intestines. We found that T cells from Ceacam1-/- mice had elevated phosphorylation of STAT3. Upon stimulation with anti-CD3+CD28, IL-2, IL-4, IL-6, or IL-12 in vitro, Ceacam1-/- T cells showed hyperphosphorylation of corresponding canonical STAT proteins, indicating that Ceacam1 can regulate the sensitivity of T cells to cytokines and TCR stimulation.
Authors: S.X. Lu, L. Willis, A.-M. Charbonneau-Allard, R. Atallah, A.M. Holland, C. Turbide, V.M. Hubbard, J.A. Rotolo, O.M. Smith, D. Suh, C. King, U.K. Rao, N. Yim, A. Kochman, J.L. Bautista, R.R. Jenq, J.L. Zakrzewski, H. Tran, O. Penack, I.-K. Na, M. Chow, J. Lin, J. Cabrera-Perez, C. Liu, G. Murphy, O. Alpdogan, R.S. Blumberg, F. Macian, K.V. Holmes, N. Beauchemin, M.R.M. van den Brink
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,650
OpenAlex ID: W2159014921