Work

Recent developments in the treatment of age-related macular degeneration

Year: 2014

Type: article

Abstract: Age-related macular degeneration (AMD) is a common cause of visual loss in the elderly, with increasing prevalence due to increasing life expectancy. While the introduction of anti-VEGF therapy has improved outcomes, there are still major unmet needs and gaps in the understanding of underlying biological processes. These include early, intermediate, and atrophic disease stages. Recent studies have assessed therapeutic approaches addressing various disease-associated pathways, including complement inhibitors. Drug-delivery aspects are also relevant, as many agents have to be administered repeatedly. Herein, relevant pathogenetic factors and underlying mechanisms as well as recent and potential therapeutic approaches are reviewed.

Source: Journal of Clinical Investigation

DOI: 10.1172/jci71029

Authors: Frank G. Holz, Steffen Schmitz-Valckenberg, Monika Fleckenstein

Institutions: Novartis (Switzerland), University of Bonn, Genentech

Language: English

Topic: Retinal Diseases and Treatments

Subfield: Ophthalmology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Deutsche Forschungsgemeinschaft, Bundesministerium für Bildung und Forschung, Rheinische Friedrich-Wilhelms-Universität Bonn