Work

Antifungal Combinations against Candida albicans Biofilms In Vitro

Year: 2003

Type: article

Abstract: Candida biofilms display increased resistance to most antifungal agents. We have evaluated the efficacy of combinations of fluconazole (FLC), amphotericin B, and caspofungin (CSP) against Candida albicans biofilms in vitro. Indifference was observed for all the combinations of paired antifungal agents when a checkerboard titration method was used. Time-kill experiments revealed an antagonistic effect of high FLC doses with CSP.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.47.11.3657-3659.2003

Authors: Stefano P. Bachmann, Gordon Ramage, Kacy VandeWalle, Thomas F. Patterson, Brian L. Wickes, José L. López-Ribot

Institution: The University of Texas at San Antonio Health Science Center

Language: English

Topic: Antifungal resistance and susceptibility

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of Dental and Craniofacial Research