Work

Transient spleen enlargement in peripheral blood progenitor cell donors given G-CSF

Year: 2004

Type: article

Abstract: The administration of granulocyte colony-stimulating factor (G-CSF) to peripheral blood progenitor cell (PBPC) donors causes spleen length to increase, but the duration of enlargement is not known. Eighteen healthy subjects were given 10 microg/kg of G-CSF for 5 days and a PBSC concentrate was collected by apheresis. Ultrasound scans were used to assess craniocaudal spleen length before and after G-CSF administration. Mean spleen length increased from a baseline length of 10.7 +/- 1.3 cm to 12.1 +/- 1.2 cm on the apheresis day (p < 0.001). Ten days after apheresis, spleen length fell to 10.5 +/- 1.2 cm and did not differ from baseline levels (p = 0.57), but in 3 subjects remained 0.5 cm greater than baseline length. Increases in spleen length in PBPC donors are transient and reversible.

Source: Journal of Translational Medicine

DOI: 10.1186/1479-5876-2-25

Authors: David F Stroncek, Kristin Dittmar, Thomas Shawker, Angela Heatherman, Susan F Leitman

Institutions: National Institutes of Health, National Institutes of Health Clinical Center

Language: English

Topic: Hematopoietic Stem Cell Transplantation

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,890